Study of secretion melatonin in elderly persons

Hormones likes estrogens, testosterone, DHEA, cortisol are subjet of circadian or seasonal fluctuations.

For same of them the regulation system is well documented.

Even their progressive decline durin aging is well documented.

If an adequate substitution of same or all of these hormones are therapeutically useful is still objetive of clinical studies.

Generally we have to distinguish between hormone replacement therapy, where the natural rhythm will be restored and pharmacological applications, where intrinsic potentials of the single hormones are request.

Additionally, special attention have to be done on the interaction of the different hormones.

Given the fact that al these elderly patients showed sever alteration of their melatonin secretion paterns, the effects of an special galenic formulation to substitute melatonin was tested.

The results suggest that melatonin have to be replaced in elderly persons in a special way, wich permits to mimic the phisiological secretion pattern o melatonin for getting the best results to rebalance the circadian system and therefore to restore same endocrine abnormalities

We Conclude that melatonin administration could influence not only the sleep pattern but also the circadian clock and therefore probably other endocrine rhythm like DHEA, testosterone and estrogens, wick are presenting own circadian secretion rhythms.

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